← Pipeline|Semacilimab

Semacilimab

Phase 3
SEA-6175
Source: Trial-derived·Trials: 1
Modality
Vaccine
MOA
BETi
Target
SHP2
Pathway
NF-κB
Pancreatic CaGIST
Development Pipeline
Preclinical
~Feb 2013
~May 2014
Phase 1
~Aug 2014
~Nov 2015
Phase 2
~Feb 2016
~May 2017
Phase 3
Aug 2017
Feb 2030
Phase 3Current
NCT05817364
2,937 pts·GIST
2017-082030-02·Recruiting
2,937 total pts1 indication
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (1)
2030-02-043.8y awayPh3 Readout· GIST
Trial Timeline
Q3Q42018Q2Q3Q42019Q2Q3Q42020Q2Q3Q42021Q2Q3Q42022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q42029Q2Q3Q42030Q2
P3
Recruit…
Catalysts
Ph3 Readout
2030-02-04 · 3.8y away
GIST
Recruiting|StartCompletionToday
Trials (1)
NCTPhaseIndicationStatusNEP
NCT05817364Phase 3GISTRecruiting2937HbA1c
Competitors (10)
DrugCompanyPhaseTargetMOA
JNJ-179Johnson & JohnsonApprovedKRASG12CBETi
LLY-1592Eli LillyNDA/BLAFGFRBETi
NVS-5126NovartisPhase 3SHP2PI3Ki
MRK-1380Merck & CoPreclinicalSHP2SOS1i
SovarapivirAbbViePhase 2/3IL-13BETi
ABB-1817AbbViePhase 3SHP2WRNi
AZN-8281AstraZenecaPhase 1SHP2BTKi
AZN-8478AstraZenecaNDA/BLASHP2KRASG12Ci
BAY-8733BayerPreclinicalAuroraABETi
MRN-7409ModernaNDA/BLASHP2CDK2i