← Pipeline|MRK-474

MRK-474

Phase 3
Source: Trial-derived·Trials: 1
Modality
Gene Editing
MOA
FGFRi
Target
PCSK9
Pathway
NF-κB
UCGastric CaGBM
Development Pipeline
Preclinical
~Jul 2019
~Oct 2020
Phase 1
~Jan 2021
~Apr 2022
Phase 2
~Jul 2022
~Oct 2023
Phase 3
Jan 2024
Sep 2031
Phase 3Current
NCT05526177
1,710 pts·UC
2024-012031-09·Terminated
1,710 total pts1 indication
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (1)
2031-09-075.4y awayPh3 Readout· UC
Trial Timeline
2024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q42029Q2Q3Q42030Q2Q3Q42031Q2Q3Q4
P3
Termina…
Catalysts
Ph3 Readout
2031-09-07 · 5.4y away
UC
Terminated|StartCompletionToday
Trials (1)
NCTPhaseIndicationStatusNEP
NCT05526177Phase 3UCTerminated1710DOR
Competitors (10)
DrugCompanyPhaseTargetMOA
LLY-9749Eli LillyPhase 3C5FGFRi
LLY-1956Eli LillyPhase 1/2BCMAFGFRi
ZanusertibAbbVieApprovedPCSK9KRASG12Di
GIL-4361Gilead SciencesPreclinicalPCSK9STINGag
REG-2172RegeneronPhase 1/2PCSK9Anti-Tau
BMR-8377BioMarinPhase 1/2PCSK9BTKi
CapifutibatinibIncytePhase 3PCSK9BCL-2i
INC-5849IncytePhase 2PCSK9STINGag
SRP-9822SareptaPhase 3SOS1FGFRi
TalatapinarofSamsung BiologicsPhase 1/2PCSK9SHP2i