← Pipeline|Motazasiran

Motazasiran

Preclinical
GLS-4357
Source: Trial-derived·Trials: 2
Modality
mAb
MOA
TROP-2 ADC
Target
BCMA
Pathway
Epigenetic
HSACC
Development Pipeline
Preclinical
Jul 2017
Apr 2026
PreclinicalCurrent
NCT08320497
936 pts·ACC
2017-072026-03·Active
NCT04427847
2,549 pts·ACC
2018-072026-04·Completed
3,485 total pts1 indication
Phase 1
Phase 2
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (2)
2026-03-142w agoInterim· ACC
2026-04-066d awayInterim· ACC
Trial Timeline
Q3Q42018Q2Q3Q42019Q2Q3Q42020Q2Q3Q42021Q2Q3Q42022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2
Preclinical
Active
Preclinical
Complet…
Catalysts
Interim
2026-03-14 · 2w ago
ACC
Interim
2026-04-06 · 6d away
ACC
ActiveCompleted|StartCompletionToday
Trials (2)
NCTPhaseIndicationStatusNEP
NCT08320497PreclinicalACCActive936LiverFat
NCT04427847PreclinicalACCCompleted2549DOR
Competitors (10)
DrugCompanyPhaseTargetMOA
LLY-1956Eli LillyPhase 1/2BCMAFGFRi
ABB-8696AbbViePhase 3BCMAAnti-Aβ
AZN-4015AstraZenecaPreclinicalBCMAPCSK9i
BAY-6520BayerPhase 2AHRTROP-2 ADC
BemazumabRegeneronPhase 1VEGFTROP-2 ADC
REG-2328RegeneronPhase 1BCMACDK2i
AdagratapinarofVertex PharmaPreclinicalBCMAJAK1i
BGN-6990BeiGenePhase 2/3BCMAAuroraAi
BGN-3305BeiGenePhase 2BCMAAnti-Tau
GMA-5010GenmabPhase 3JAK2TROP-2 ADC