← Pipeline|GRF-4589

GRF-4589

Phase 2
Source: Trial-derived·Trials: 1
Modality
ADC
MOA
CAR-T BCMA
Target
SHP2
Pathway
RAS/MAPK
GISTDMD
Development Pipeline
Preclinical
~Mar 2017
~Jun 2018
Phase 1
~Sep 2018
~Dec 2019
Phase 2
Mar 2020
May 2030
Phase 2Current
NCT05354139
2,429 pts·GIST
2020-032030-05·Completed
2,429 total pts1 indication
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (1)
2030-05-274.2y awayPh2 Data· GIST
Trial Timeline
2020Q2Q3Q42021Q2Q3Q42022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q42029Q2Q3Q42030Q2Q3
P2
Complet…
Catalysts
Ph2 Data
2030-05-27 · 4.2y away
GIST
Completed|StartCompletionToday
Trials (1)
NCTPhaseIndicationStatusNEP
NCT05354139Phase 2GISTCompleted2429DAS28
Competitors (10)
DrugCompanyPhaseTargetMOA
VoxacilimabPfizerPhase 2TYK2CAR-T BCMA
NVS-5126NovartisPhase 3SHP2PI3Ki
MRK-1380Merck & CoPreclinicalSHP2SOS1i
ABB-1817AbbViePhase 3SHP2WRNi
AZN-8281AstraZenecaPhase 1SHP2BTKi
AZN-8478AstraZenecaNDA/BLASHP2KRASG12Ci
NVO-9087Novo NordiskPhase 1/2TauCAR-T BCMA
FixazanubrutinibAmgenPhase 2PI3KαCAR-T BCMA
REG-8074RegeneronPhase 2/3KRASG12CCAR-T BCMA
MRN-7409ModernaNDA/BLASHP2CDK2i