← Pipeline|PRM-116

PRM-116

NDA/BLA
Source: Trial-derived·Trials: 2
Modality
mRNA
MOA
CAR-T CD19
Target
C5
Pathway
Complement
EoE
Development Pipeline
Preclinical
~Apr 2015
~Jul 2016
Phase 1
~Oct 2016
~Jan 2018
Phase 2
~Apr 2018
~Jul 2019
Phase 3
~Oct 2019
~Jan 2021
NDA/BLA
Apr 2021
Mar 2026
NDA/BLACurrent
NCT08551907
2,890 pts·EoE
2021-042026-03·Terminated
NCT07413112
2,136 pts·EoE
2025-012025-01·Terminated
5,026 total pts1 indication
Approved
CompletedCurrentUpcoming
Catalysts (3)
2025-01-151.2y agoPh3 Readout· EoE
2025-12-163mo agoBTD· EoE
2026-03-231w agoPh3 Readout· EoE
Trial Timeline
Q2Q3Q42022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2
NDA/BLA
Termina…
NDA/BLA
Termina…
Catalysts
Ph3 Readout
2025-01-15 · 1.2y ago
EoE
BTD
2025-12-16 · 3mo ago
EoE
Ph3 Readout
2026-03-23 · 1w ago
EoE
Terminated|StartCompletionToday
Trials (2)
NCTPhaseIndicationStatusNEP
NCT08551907NDA/BLAEoETerminated2890EASI-75
NCT07413112NDA/BLAEoETerminated2136EFS
Competitors (10)
DrugCompanyPhaseTargetMOA
LLY-9749Eli LillyPhase 3C5FGFRi
LLY-1184Eli LillyNDA/BLAC5CD3xCD20
RHH-1546RochePhase 2/3C5CAR-T CD19
DatoglumideAbbVieApprovedCFTRCAR-T CD19
BAY-6035BayerPhase 1C5Anti-Aβ
GIL-2259Gilead SciencesApprovedSMN2CAR-T CD19
BII-4342BiogenPhase 2/3CGRPCAR-T CD19
ARG-1250ArgenxPhase 2C5GLP-1ag
ElratapinarofHalozymePhase 2C5AHRant
HAL-1232HalozymeApprovedC5SOS1i