← Pipeline|BRK-4512

BRK-4512

Preclinical
Source: Trial-derived·Trials: 2
Modality
ERT
MOA
CAR-T CD19
Target
GIP-R
Pathway
RNA Splicing
MGPAH
Development Pipeline
Preclinical
Nov 2022
Sep 2028
PreclinicalCurrent
NCT05795962
1,764 pts·PAH
2022-112025-04·Recruiting
NCT08547622
259 pts·PAH
2024-012028-09·Terminated
2,023 total pts1 indication
Phase 1
Phase 2
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (2)
2025-04-2411mo agoInterim· PAH
2028-09-082.4y awayInterim· PAH
Trial Timeline
Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q4
Preclinical
Recruit…
Preclinical
Termina…
Catalysts
Interim
2025-04-24 · 11mo ago
PAH
Interim
2028-09-08 · 2.4y away
PAH
RecruitingTerminated|StartCompletionToday
Trials (2)
NCTPhaseIndicationStatusNEP
NCT05795962PreclinicalPAHRecruiting1764eGFR
NCT08547622PreclinicalPAHTerminated259Biomarker
Competitors (10)
DrugCompanyPhaseTargetMOA
JNJ-5094Johnson & JohnsonPhase 2/3GIP-REGFRi
RHH-1546RochePhase 2/3C5CAR-T CD19
RHH-3592RochePhase 1/2GIP-RBCL-2i
DatoglumideAbbVieApprovedCFTRCAR-T CD19
AZN-5978AstraZenecaPhase 2/3GIP-RAHRant
IvotuximabGSKNDA/BLAGIP-RKRASG12Di
GIL-2259Gilead SciencesApprovedSMN2CAR-T CD19
ElrarapivirRegeneronPhase 1GIP-RCl18.2
BII-4342BiogenPhase 2/3CGRPCAR-T CD19
CapifutibatinibIntra-CellularPhase 3GIP-RVEGFi