← Pipeline|Polacagene

Polacagene

Approved
RED-3557
Source: Trial-derived·Trials: 1
Modality
Gene Editing
MOA
AHRant
Target
RET
Pathway
Hedgehog
UC
Development Pipeline
Preclinical
~Nov 2013
~Feb 2015
Phase 1
~May 2015
~Aug 2016
Phase 2
~Nov 2016
~Feb 2018
Phase 3
~May 2018
~Aug 2019
NDA/BLA
~Nov 2019
~Feb 2021
Approved
May 2021
Jun 2027
ApprovedCurrent
NCT06651615
55 pts·UC
2021-052027-06·Completed
55 total pts1 indication
CompletedCurrentUpcoming
Catalysts (2)
2025-11-154mo agoAdCom· UC
2027-06-041.2y awayPh3 Readout· UC
Trial Timeline
Q2Q3Q42022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3
Approved
Complet…
Catalysts
AdCom
2025-11-15 · 4mo ago
UC
Ph3 Readout
2027-06-04 · 1.2y away
UC
Completed|StartCompletionToday
Trials (1)
NCTPhaseIndicationStatusNEP
NCT06651615ApprovedUCCompleted55ACR20
Competitors (10)
DrugCompanyPhaseTargetMOA
RHH-5389RochePreclinicalRETSTINGag
FixanesiranAbbViePreclinicalRETJAK1/2i
AZN-5978AstraZenecaPhase 2/3GIP-RAHRant
BMY-8678Bristol-Myers SquibbApprovedRETMDM2i
VRT-1576Vertex PharmaPhase 2/3RETSHP2i
BII-5449BiogenPhase 3FXIaAHRant
ARG-3458ArgenxPreclinicalRETIL-17i
ElratapinarofHalozymePhase 2C5AHRant
NidaratamabExelixisPhase 3FLT3AHRant
NidaratamabKrystal BiotechPreclinicalRETIL-17i