← Pipeline|Motavorutinib

Motavorutinib

Phase 3
AMG-491
Source: Trial-derived·Trials: 1
Modality
ADC
MOA
JAK1/2i
Target
CDK4/6
Pathway
Cell Cycle
LN
Development Pipeline
Preclinical
~Oct 2013
~Jan 2015
Phase 1
~Apr 2015
~Jul 2016
Phase 2
~Oct 2016
~Jan 2018
Phase 3
Apr 2018
Sep 2028
Phase 3Current
NCT08560224
567 pts·LN
2018-042028-09·Completed
567 total pts1 indication
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (2)
2025-11-174mo agoFast Track· LN
2028-09-122.5y awayPh3 Readout· LN
Trial Timeline
Q2Q3Q42019Q2Q3Q42020Q2Q3Q42021Q2Q3Q42022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q4
P3
Complet…
Catalysts
Fast Track
2025-11-17 · 4mo ago
LN
Ph3 Readout
2028-09-12 · 2.5y away
LN
Completed|StartCompletionToday
Trials (1)
NCTPhaseIndicationStatusNEP
NCT08560224Phase 3LNCompleted567DOR
Competitors (10)
DrugCompanyPhaseTargetMOA
FixanesiranAbbViePreclinicalRETJAK1/2i
RibozanubrutinibRegeneronPhase 1CDK4/6IL-13i
VRT-9481Vertex PharmaPhase 1/2MeninJAK1/2i
MRN-5715ModernaNDA/BLACDK4/6AuroraAi
SovarelsinBioMarinPhase 2CFTRJAK1/2i
PeminaritideSareptaNDA/BLAPLK4JAK1/2i
NiramavacamtenHansoh PharmaPhase 2SGLT2JAK1/2i
ElralucimabAxsomePhase 2CDK4/6MDM2i
TalazumabZealand PharmaPhase 1/2WEE1JAK1/2i
CGO-9628CG OncologyPhase 2/3AuroraAJAK1/2i