← Pipeline|Talazasiran

Talazasiran

Approved
RGN-7746
Source: Trial-derived·Trials: 1
Modality
mAb
MOA
EZH2i
Target
PLK4
Pathway
RAS/MAPK
ADPKDASCSU
Development Pipeline
Preclinical
~May 2018
~Aug 2019
Phase 1
~Nov 2019
~Feb 2021
Phase 2
~May 2021
~Aug 2022
Phase 3
~Nov 2022
~Feb 2024
NDA/BLA
~May 2024
~Aug 2025
Approved
Nov 2025
May 2027
ApprovedCurrent
NCT05803176
2,091 pts·ADPKD
2025-112027-05·Not yet recruiting
2,091 total pts1 indication
CompletedCurrentUpcoming
Catalysts (1)
2027-05-191.1y awayPh3 Readout· ADPKD
Trial Timeline
2026Q2Q3Q42027Q2
Approved
Not yet…
Catalysts
Ph3 Readout
2027-05-19 · 1.1y away
ADPKD
Not yet recruiting|StartCompletionToday
Trials (1)
NCTPhaseIndicationStatusNEP
NCT05803176ApprovedADPKDNot yet recr...2091UPDRS
Competitors (10)
DrugCompanyPhaseTargetMOA
AdagrazumabNovartisPhase 2/3Cl18.2EZH2i
RibotuximabMerck & CoPhase 2GPRC5DEZH2i
NVO-9615Novo NordiskPhase 2/3PRMT5EZH2i
BemanesiranBioNTechPhase 3PLK4HPK1i
PeminaritideSareptaNDA/BLAPLK4JAK1/2i
PexaosocimabUnited TherapeuticsNDA/BLAPLK4KRASG12Ci
PolalucimabJazz PharmaPreclinicalPLK4EZH2i
ASN-7038Ascendis PharmaPhase 3VEGFEZH2i
ILM-2412IlluminaPhase 3PLK4AuroraAi
ROI-3353Roivant SciencesPhase 1/2PLK4IL-13i