← Pipeline|Mavunesiran

Mavunesiran

Preclinical
GUT-5418
Source: Trial-derived·Trials: 1
Modality
Nanobody
MOA
HPK1i
Target
JAK1
Pathway
Angiogenesis
LGSObesityBCC
Development Pipeline
Preclinical
Jul 2020
Mar 2030
PreclinicalCurrent
NCT05579887
165 pts·BCC
2020-072030-03·Terminated
165 total pts1 indication
Phase 1
Phase 2
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (2)
2025-11-284mo agoNDA· LGS
2030-03-164.0y awayInterim· BCC
Trial Timeline
Q3Q42021Q2Q3Q42022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q42029Q2Q3Q42030Q2
Preclinical
Termina…
Catalysts
NDA
2025-11-28 · 4mo ago
LGS
Interim
2030-03-16 · 4.0y away
BCC
Terminated|StartCompletionToday
Trials (1)
NCTPhaseIndicationStatusNEP
NCT05579887PreclinicalBCCTerminated165BodyWt
Competitors (10)
DrugCompanyPhaseTargetMOA
PFE-1944PfizerNDA/BLAAPOC3HPK1i
IvorelsinEli LillyApprovedJAK1Menini
RHH-974RochePreclinicalJAK1MALT1i
NVS-6974NovartisPreclinicalCD19HPK1i
ABB-7516AbbViePhase 3PD-L1HPK1i
FixatenlimabGSKPhase 1/2JAK1CDK4/6i
GIL-8529Gilead SciencesPhase 1/2JAK1EGFRi
BemanesiranBioNTechPhase 3PLK4HPK1i
BII-5240BiogenPhase 2/3MALT1HPK1i
SemasacituzumabIlluminaPhase 3Nectin-4HPK1i