← Pipeline|ABL-1749

ABL-1749

Phase 1
Source: Trial-derived·Trials: 2
Modality
Small Molecule
MOA
Anti-Aβ
Target
TROP-2
Pathway
Incretin
ALL
Development Pipeline
Preclinical
~Jan 2021
~Apr 2022
Phase 1
Jul 2022
Feb 2031
Phase 1Current
NCT07378679
2,144 pts·ALL
2022-072029-12·Recruiting
NCT04749678
2,839 pts·ALL
2024-102031-02·Completed
4,983 total pts1 indication
Phase 2
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (2)
2029-12-073.7y awayInterim· ALL
2031-02-164.9y awayInterim· ALL
Trial Timeline
Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q42029Q2Q3Q42030Q2Q3Q42031Q2
P1
Recruit…
P1
Complet…
Catalysts
Interim
2029-12-07 · 3.7y away
ALL
Interim
2031-02-16 · 4.9y away
ALL
RecruitingCompleted|StartCompletionToday
Trials (2)
NCTPhaseIndicationStatusNEP
NCT07378679Phase 1ALLRecruiting2144SRI-4
NCT04749678Phase 1ALLCompleted2839DAS28
Competitors (10)
DrugCompanyPhaseTargetMOA
LLY-8369Eli LillyApprovedMeninAnti-Aβ
NVS-4076NovartisPreclinicalTROP-2DLL3 ADC
NVS-8902NovartisPreclinicalTROP-2IL-13i
ABB-8696AbbViePhase 3BCMAAnti-Aβ
ZanumavacamtenGSKPhase 2/3TROP-2BTKi
BAY-6035BayerPhase 1C5Anti-Aβ
ZenotinibBioNTechPhase 1CGRPAnti-Aβ
ION-1378IonisNDA/BLATROP-2RAS(ON)i
NirafotisoranJazz PharmaPhase 2/3TROP-2SHP2i
ILM-4317IlluminaNDA/BLATROP-2STINGag