← Pipeline|Fixanesiran

Fixanesiran

Preclinical
ABB-4193
Source: Trial-derived·Trials: 2
Modality
Radioligand
MOA
JAK1/2i
Target
RET
Pathway
Checkpoint
Endometrial CaHSTTR Amyloidosis
Development Pipeline
Preclinical
Sep 2019
Apr 2029
PreclinicalCurrent
NCT08457379
945 pts·Endometrial Ca
2023-102026-06·Active
NCT03575505
783 pts·Endometrial Ca
2019-092029-04·Recruiting
1,728 total pts1 indication
Phase 1
Phase 2
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (2)
2026-06-152mo awayInterim· Endometrial Ca
2029-04-113.0y awayInterim· Endometrial Ca
Trial Timeline
Q3Q42020Q2Q3Q42021Q2Q3Q42022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q42029Q2
Preclinical
Recruit…
Preclinical
Active
Catalysts
Interim
2026-06-15 · 2mo away
Endometrial Ca
Interim
2029-04-11 · 3.0y away
Endometrial Ca
RecruitingActive|StartCompletionToday
Trials (2)
NCTPhaseIndicationStatusNEP
NCT08457379PreclinicalEndometrial CaActive945PASI75
NCT03575505PreclinicalEndometrial CaRecruiting783DAS28
Competitors (10)
DrugCompanyPhaseTargetMOA
RHH-5389RochePreclinicalRETSTINGag
BMY-8678Bristol-Myers SquibbApprovedRETMDM2i
MotavorutinibAmgenPhase 3CDK4/6JAK1/2i
VRT-9481Vertex PharmaPhase 1/2MeninJAK1/2i
VRT-1576Vertex PharmaPhase 2/3RETSHP2i
ARG-3458ArgenxPreclinicalRETIL-17i
SovarelsinBioMarinPhase 2CFTRJAK1/2i
PeminaritideSareptaNDA/BLAPLK4JAK1/2i
NiramavacamtenHansoh PharmaPhase 2SGLT2JAK1/2i
NidaratamabKrystal BiotechPreclinicalRETIL-17i