← Pipeline|Doxafotisoran

Doxafotisoran

NDA/BLA
457-6977
Source: Trial-derived·Trials: 2
Modality
Cell Therapy
MOA
MALT1i
Target
TIM-3
Pathway
mTOR
PompeBCCLN
Development Pipeline
Preclinical
~Jan 2018
~Apr 2019
Phase 1
~Jul 2019
~Oct 2020
Phase 2
~Jan 2021
~Apr 2022
Phase 3
~Jul 2022
~Oct 2023
NDA/BLA
Jan 2024
Oct 2027
NDA/BLACurrent
NCT04473564
2,719 pts·LN
2025-10TBD·Not yet recruiting
NCT05657890
1,529 pts·Pompe
2024-012027-10·Recruiting
4,248 total pts2 indications
Approved
CompletedCurrentUpcoming
Catalysts (1)
2027-10-111.5y awayPh3 Readout· Pompe
Trial Timeline
2024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q4
NDA/BLA
Recruit…
NDA/BLA
Not yet…
Catalysts
Ph3 Readout
2027-10-11 · 1.5y away
Pompe
RecruitingNot yet recruiting|StartCompletionToday
Trials (2)
NCTPhaseIndicationStatusNEP
NCT04473564NDA/BLALNNot yet recr...2719ACR20
NCT05657890NDA/BLAPompeRecruiting1529eGFR
Competitors (10)
DrugCompanyPhaseTargetMOA
JNJ-2735Johnson & JohnsonPhase 2/3Cl18.2MALT1i
RiboinavolisibJohnson & JohnsonPhase 2/3GLP-1RMALT1i
RHH-974RochePreclinicalJAK1MALT1i
NVS-3297NovartisPreclinicalCDK2MALT1i
ABB-8985AbbViePhase 2CD20MALT1i
REG-6699RegeneronPhase 2/3TIM-3FcRni
SovarelsinAlnylamPhase 2/3LAG-3MALT1i
ITC-6153Intra-CellularPhase 3KRASG12CMALT1i
NidasacituzumabUnited TherapeuticsPhase 1/2TIM-3ALKi
GelisertibSamsung BiologicsApprovedIL-23MALT1i