← Pipeline|452-308

452-308

NDA/BLA
Source: Trial-derived·Trials: 2
Modality
Peptide
MOA
PARPi
Target
TNFα
Pathway
RAS/MAPK
AMLAtopic Derm
Development Pipeline
Preclinical
~Jul 2014
~Oct 2015
Phase 1
~Jan 2016
~Apr 2017
Phase 2
~Jul 2017
~Oct 2018
Phase 3
~Jan 2019
~Apr 2020
NDA/BLA
Jul 2020
Feb 2029
NDA/BLACurrent
NCT08909471
235 pts·AML
2020-072029-02·Active
NCT05216372
1,321 pts·AML
2024-122028-06·Completed
1,556 total pts1 indication
Approved
CompletedCurrentUpcoming
Catalysts (2)
2028-06-182.2y awayPh3 Readout· AML
2029-02-162.9y awayPh3 Readout· AML
Trial Timeline
Q3Q42021Q2Q3Q42022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q42029Q2
NDA/BLA
Active
NDA/BLA
Complet…
Catalysts
Ph3 Readout
2028-06-18 · 2.2y away
AML
Ph3 Readout
2029-02-16 · 2.9y away
AML
ActiveCompleted|StartCompletionToday
Trials (2)
NCTPhaseIndicationStatusNEP
NCT08909471NDA/BLAAMLActive235PFS
NCT05216372NDA/BLAAMLCompleted1321EFS
Competitors (10)
DrugCompanyPhaseTargetMOA
MRK-3732Merck & CoPhase 1TYK2PARPi
ABB-3951AbbViePhase 2/3TNFαCDK2i
GSK-6516GSKPhase 1/2MALT1PARPi
BAY-3684BayerApprovedPD-L1PARPi
GIL-6239Gilead SciencesPhase 2TNFαCGRPant
MRN-8225ModernaPreclinicalTNFαSGLT2i
BNT-5232BioNTechNDA/BLATIGITPARPi
ALN-3958AlnylamPhase 2MALT1PARPi
SovanaritideArgenxPhase 3TNFαBETi
CevifotisoranNeurocrineApprovedCD47PARPi