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← Pipeline|CGO-2579

CGO-2579

Approved
By CG Oncology
Source: Trial-derived·Trials: 4
Modality
mRNA
MOA
RAS(ON)i
Target
TIGIT
Pathway
Amyloid
Hemophilia ARSVPBC
Development Pipeline
Preclinical
~Dec 2009
→ ~Mar 2011
Phase 1
~Jun 2011
→ ~Sep 2012
Phase 2
~Dec 2012
→ ~Mar 2014
Phase 3
~Jun 2014
→ ~Sep 2015
NDA/BLA
~Dec 2015
→ ~Mar 2017
Approved
Jun 2017
→ Nov 2030
ApprovedCurrent
NCT05649699
1,760 pts·Hemophilia A
2022-12→2028-11·Terminated
NCT07839774
915 pts·Hemophilia A
2019-07→2028-09·Recruiting
NCT07230849
2,277 pts·Hemophilia A
2017-11→2026-03·Completed
+1 more trial
6,457 total pts2 indications
CompletedCurrentUpcoming
Catalysts (4)
2026-03-054w agoPh3 Readout· Hemophilia A
2028-09-152.5y awayPh3 Readout· Hemophilia A
2028-11-152.6y awayPh3 Readout· Hemophilia A
2030-11-064.6y awayPh3 Readout· PBC
Trial Timeline
Q2Q3Q42018Q2Q3Q42019Q2Q3Q42020Q2Q3Q42021Q2Q3Q42022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q42029Q2Q3Q42030Q2Q3Q4
Approved
Not yet…
Approved
Complet…
Approved
Recruit…
Approved
Termina…
Catalysts
Ph3 Readout
2026-03-05 · 4w ago
Hemophilia A
Ph3 Readout
2028-09-15 · 2.5y away
Hemophilia A
Ph3 Readout
2028-11-15 · 2.6y away
Hemophilia A
Ph3 Readout
2030-11-06 · 4.6y away
PBC
RecruitingCompletedTerminatedNot yet recruiting|StartCompletionToday
Trials (4)
NCTPhaseIndicationStatusNEP
NCT05649699ApprovedHemophilia ATerminated1760Biomarker
NCT07839774ApprovedHemophilia ARecruiting9156MWD
NCT07230849ApprovedHemophilia ACompleted2277BodyWt
NCT08590467ApprovedPBCNot yet recr...1505Safety
Competitors (10)
DrugCompanyPhaseTargetMOA
ZanuderotideJohnson & JohnsonPhase 2/3TIGITGLP-1/GIP
MRK-6781Merck & CoApprovedTIGITRAS(ON)i
SNY-9073SanofiPhase 2B7-H3RAS(ON)i
PexamavacamtenDaiichi SankyoNDA/BLATIGITCD3xCD20
TixarelsinVertex PharmaPhase 1ALKRAS(ON)i
BNT-5232BioNTechNDA/BLATIGITPARPi
ALN-8757AlnylamPreclinicalTIGITCFTRmod
MiritinibNeurocrinePhase 3TIGITSTINGag
FixatuximabLegend BiotechPreclinicalCFTRRAS(ON)i
ION-1378IonisNDA/BLATROP-2RAS(ON)i