← Pipeline|Talazasiran

Talazasiran

NDA/BLA
KYM-1258
Source: Trial-derived·Trials: 1
Modality
Gene Editing
MOA
CFTRmod
Target
MET
Pathway
Apoptosis
HSNBGIST
Development Pipeline
Preclinical
~Jan 2019
~Apr 2020
Phase 1
~Jul 2020
~Oct 2021
Phase 2
~Jan 2022
~Apr 2023
Phase 3
~Jul 2023
~Oct 2024
NDA/BLA
Jan 2025
Sep 2027
NDA/BLACurrent
NCT06096581
461 pts·HS
2025-012027-09·Terminated
461 total pts1 indication
Approved
CompletedCurrentUpcoming
Catalysts (1)
2027-09-031.4y awayPh3 Readout· HS
Trial Timeline
2025Q2Q3Q42026Q2Q3Q42027Q2Q3
NDA/BLA
Termina…
Catalysts
Ph3 Readout
2027-09-03 · 1.4y away
HS
Terminated|StartCompletionToday
Trials (1)
NCTPhaseIndicationStatusNEP
NCT06096581NDA/BLAHSTerminated461NT-proBNP
Competitors (10)
DrugCompanyPhaseTargetMOA
LLY-4358Eli LillyPhase 3B7-H3CFTRmod
GelinaritideAbbViePreclinicalFcRnCFTRmod
SNY-5783SanofiPhase 1/2METSTINGag
SotosacituzumabVertex PharmaPhase 1METTYK2i
DarafutibatinibBioNTechPreclinicalPRMT5CFTRmod
ALN-8757AlnylamPreclinicalTIGITCFTRmod
RVM-274Revolution MedicinesPhase 3METKIF18Ai
IvotuximabMadrigal PharmaPhase 2CD123CFTRmod
DAW-8159Day One BioPhase 2PSMACFTRmod
RAP-2478Rapport TherPhase 3METCDK4/6i