← Pipeline|Polatapinarof

Polatapinarof

Approved
PCV-1457
Source: Trial-derived·Trials: 3
Modality
Gene Therapy
MOA
JAK1i
Target
AuroraA
Pathway
Checkpoint
MG
Development Pipeline
Preclinical
~Mar 2013
~Jun 2014
Phase 1
~Sep 2014
~Dec 2015
Phase 2
~Mar 2016
~Jun 2017
Phase 3
~Sep 2017
~Dec 2018
NDA/BLA
~Mar 2019
~Jun 2020
Approved
Sep 2020
Sep 2030
ApprovedCurrent
NCT05452530
70 pts·MG
2025-082026-04·Active
NCT07541719
1,222 pts·MG
2023-102030-09·Not yet recruiting
NCT05674204
304 pts·MG
2020-092026-01·Completed
1,596 total pts1 indication
CompletedCurrentUpcoming
Catalysts (3)
2026-01-013mo agoPh3 Readout· MG
2026-04-081w awayPh3 Readout· MG
2030-09-014.4y awayPh3 Readout· MG
Trial Timeline
Q3Q42021Q2Q3Q42022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q42029Q2Q3Q42030Q2Q3Q4
Approved
Complet…
Approved
Not yet…
Approved
Active
Catalysts
Ph3 Readout
2026-01-01 · 3mo ago
MG
Ph3 Readout
2026-04-08 · 1w away
MG
Ph3 Readout
2030-09-01 · 4.4y away
MG
ActiveCompletedNot yet recruiting|StartCompletionToday
Trials (3)
NCTPhaseIndicationStatusNEP
NCT05452530ApprovedMGActive70OS
NCT07541719ApprovedMGNot yet recr...1222CR
NCT05674204ApprovedMGCompleted304eGFR
Competitors (10)
DrugCompanyPhaseTargetMOA
JNJ-7458Johnson & JohnsonPhase 1/2PD-1JAK1i
GeliderotideSanofiPhase 1/2PRMT5JAK1i
MotarapivirGSKPreclinicalAuroraAIL-23i
BAY-8733BayerPreclinicalAuroraABETi
PexaosocimabDaiichi SankyoPhase 2PD-1JAK1i
AdagratapinarofVertex PharmaPreclinicalBCMAJAK1i
BNT-8090BioNTechPhase 2AuroraAPD-L1i
ARG-6988ArgenxPreclinicalAuroraACDK2i
ARG-1924ArgenxPreclinicalDLL3JAK1i
ROI-1081Roivant SciencesPhase 1/2PI3KαJAK1i