← Pipeline|Riluzasiran

Riluzasiran

Phase 2/3
ACL-5354
Source: Trial-derived·Trials: 1
Modality
Bispecific Ab
MOA
BiTE
Target
SHP2
Pathway
mTOR
NSCLCEpilepsy
Development Pipeline
Preclinical
~Apr 2022
~Jul 2023
Phase 1
~Oct 2023
~Jan 2025
Phase 2
Apr 2025
Oct 2029
Phase 2Current
NCT08280922
1,083 pts·Epilepsy
2025-042029-10·Active
1,083 total pts1 indication
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (2)
2026-04-284w awayConference· Epilepsy
2029-10-033.5y awayPh3 Readout· Epilepsy
Trial Timeline
Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q42029Q2Q3Q4
P2/3
Active
Catalysts
Conference
2026-04-28 · 4w away
Epilepsy
Ph3 Readout
2029-10-03 · 3.5y away
Epilepsy
Active|StartCompletionToday
Trials (1)
NCTPhaseIndicationStatusNEP
NCT08280922Phase 2/3EpilepsyActive1083eGFR
Competitors (10)
DrugCompanyPhaseTargetMOA
LLY-3251Eli LillyPhase 2MDM2BiTE
NVS-5126NovartisPhase 3SHP2PI3Ki
MRK-1380Merck & CoPreclinicalSHP2SOS1i
ABB-1817AbbViePhase 3SHP2WRNi
AZN-8281AstraZenecaPhase 1SHP2BTKi
AZN-8478AstraZenecaNDA/BLASHP2KRASG12Ci
ZanutinibBristol-Myers SquibbPhase 2/3APOC3BiTE
BemarelsinDaiichi SankyoPreclinicalGLP-1RBiTE
DSN-7360Daiichi SankyoApprovedSGLT2BiTE
MRN-7409ModernaNDA/BLASHP2CDK2i