← Pipeline|TOT-3942

TOT-3942

Preclinical
Source: Trial-derived·Trials: 2
Modality
ADC
MOA
PI3Ki
Target
PI3Kα
Pathway
NF-κB
GA
Development Pipeline
Preclinical
Aug 2021
Oct 2031
PreclinicalCurrent
NCT08778664
1,371 pts·GA
2023-102030-06·Active
NCT03657081
2,134 pts·GA
2021-082031-10·Recruiting
3,505 total pts1 indication
Phase 1
Phase 2
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (3)
2025-11-214mo agoEnrollment Complete· GA
2030-06-244.2y awayInterim· GA
2031-10-225.6y awayInterim· GA
Trial Timeline
Q3Q42022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q42029Q2Q3Q42030Q2Q3Q42031Q2Q3Q4
Preclinical
Recruit…
Preclinical
Active
Catalysts
Enrollment Complete
2025-11-21 · 4mo ago
GA
Interim
2030-06-24 · 4.2y away
GA
Interim
2031-10-22 · 5.6y away
GA
RecruitingActive|StartCompletionToday
Trials (2)
NCTPhaseIndicationStatusNEP
NCT08778664PreclinicalGAActive1371EASI-75
NCT03657081PreclinicalGARecruiting2134FEV1
Competitors (10)
DrugCompanyPhaseTargetMOA
VoxaderotideJohnson & JohnsonNDA/BLAPI3KαIL-13i
TiramavacamtenRochePreclinicalSGLT2PI3Ki
NVS-5126NovartisPhase 3SHP2PI3Ki
RimamavacamtenMerck & CoPhase 1PI3KαDLL3 ADC
VoxacilimabAstraZenecaPhase 1/2GLP-1RPI3Ki
CapifutibatinibSanofiApprovedPRMT5PI3Ki
RimatenlimabNovo NordiskPhase 2/3SGLT2PI3Ki
FixazanubrutinibAmgenPhase 2PI3KαCAR-T BCMA
REG-3155RegeneronPhase 1/2MDM2PI3Ki
GMA-1468GenmabNDA/BLAPI3KαWEE1i