← Pipeline|Motabrutinib

Motabrutinib

Preclinical
PRO-4487
Source: Trial-derived·Trials: 2
Modality
Bispecific Ab
MOA
CD47i
Target
Pathway
PI3K/AKT
UC
Development Pipeline
Preclinical
Feb 2023
Jul 2028
PreclinicalCurrent
NCT06290271
806 pts·UC
2025-012028-07·Terminated
NCT04590984
337 pts·UC
2023-022026-07·Terminated
1,143 total pts1 indication
Phase 1
Phase 2
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (2)
2026-07-214mo awayInterim· UC
2028-07-122.3y awayInterim· UC
Trial Timeline
2023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3
Preclinical
Termina…
Preclinical
Termina…
Catalysts
Interim
2026-07-21 · 4mo away
UC
Interim
2028-07-12 · 2.3y away
UC
Terminated|StartCompletionToday
Trials (2)
NCTPhaseIndicationStatusNEP
NCT06290271PreclinicalUCTerminated806HAM-D
NCT04590984PreclinicalUCTerminated337SeizFreq
Competitors (10)
DrugCompanyPhaseTargetMOA
PFE-7550PfizerPhase 3KIF18Ai
SotovorutinibPfizerApprovedCGRPant
NirarelsinJohnson & JohnsonPhase 2PRMT5CD47i
CevizanubrutinibJohnson & JohnsonPreclinicalFcRnCD47i
CeviglumideRocheNDA/BLAB7-H3CD47i
NVS-1475NovartisPhase 2MeninCD47i
AZN-6294AstraZenecaPhase 2/3APOC3CD47i
BemalucimabBristol-Myers SquibbPhase 1/2SGLT2i
DatobrutinibSanofiPhase 3HER2
ZenonesiranGSKPreclinicalDLL3CD47i