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← Pipeline|ZYN-1124

ZYN-1124

NDA/BLA
By Zynerba Pharma
Source: Trial-derived·Trials: 2
Modality
ERT
MOA
CD47i
Target
FLT3
Pathway
Notch
HNSCC
Development Pipeline
Preclinical
~Feb 2015
→ ~May 2016
Phase 1
~Aug 2016
→ ~Nov 2017
Phase 2
~Feb 2018
→ ~May 2019
Phase 3
~Aug 2019
→ ~Nov 2020
NDA/BLA
Feb 2021
→ Jul 2029
NDA/BLACurrent
NCT07205484
1,296 pts·HNSCC
2021-08→2028-05·Recruiting
NCT03638613
1,845 pts·HNSCC
2021-02→2029-07·Recruiting
3,141 total pts1 indication
Approved
CompletedCurrentUpcoming
Catalysts (2)
2028-05-022.1y awayPh3 Readout· HNSCC
2029-07-173.3y awayPh3 Readout· HNSCC
Trial Timeline
2021Q2Q3Q42022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q42029Q2Q3
NDA/BLA
Recruit…
NDA/BLA
Recruit…
Catalysts
Ph3 Readout
2028-05-02 · 2.1y away
HNSCC
Ph3 Readout
2029-07-17 · 3.3y away
HNSCC
Recruiting|StartCompletionToday
Trials (2)
NCTPhaseIndicationStatusNEP
NCT07205484NDA/BLAHNSCCRecruiting1296PFS
NCT03638613NDA/BLAHNSCCRecruiting1845NT-proBNP
Competitors (10)
DrugCompanyPhaseTargetMOA
JNJ-8168Johnson & JohnsonPhase 2/3FLT3GLP-1/GIP
NirarelsinJohnson & JohnsonPhase 2PRMT5CD47i
CevizanubrutinibJohnson & JohnsonPreclinicalFcRnCD47i
CeviglumideRocheNDA/BLAB7-H3CD47i
NVS-1475NovartisPhase 2MeninCD47i
AZN-6294AstraZenecaPhase 2/3APOC3CD47i
ZenonesiranGSKPreclinicalDLL3CD47i
AMG-7379AmgenPreclinicalDLL3CD47i
SotorapivirModernaApprovedFLT3TYK2i
BGN-3859BeiGeneApprovedPSMACD47i