← Pipeline|Tirazanubrutinib

Tirazanubrutinib

Approved
STR-7222
Source: Trial-derived·Trials: 1
Modality
Degrader
MOA
PI3Ki
Target
B7-H3
Pathway
DDR
CRC
Development Pipeline
Preclinical
~Jul 2010
~Oct 2011
Phase 1
~Jan 2012
~Apr 2013
Phase 2
~Jul 2013
~Oct 2014
Phase 3
~Jan 2015
~Apr 2016
NDA/BLA
~Jul 2016
~Oct 2017
Approved
Jan 2018
Dec 2031
ApprovedCurrent
NCT05881509
2,553 pts·CRC
2018-012031-12·Not yet recruiting
2,553 total pts1 indication
CompletedCurrentUpcoming
Catalysts (1)
2031-12-265.7y awayPh3 Readout· CRC
Trial Timeline
2018Q2Q3Q42019Q2Q3Q42020Q2Q3Q42021Q2Q3Q42022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q42029Q2Q3Q42030Q2Q3Q42031Q2Q3Q4
Approved
Not yet…
Catalysts
Ph3 Readout
2031-12-26 · 5.7y away
CRC
Not yet recruiting|StartCompletionToday
Trials (1)
NCTPhaseIndicationStatusNEP
NCT05881509ApprovedCRCNot yet recr...2553UPCR
Competitors (10)
DrugCompanyPhaseTargetMOA
LLY-4358Eli LillyPhase 3B7-H3CFTRmod
CeviglumideRocheNDA/BLAB7-H3CD47i
TiramavacamtenRochePreclinicalSGLT2PI3Ki
NVS-5126NovartisPhase 3SHP2PI3Ki
VoxacilimabAstraZenecaPhase 1/2GLP-1RPI3Ki
SNY-9600SanofiNDA/BLAB7-H3PD-L1i
SNY-8628SanofiNDA/BLAB7-H3TYK2i
CapifutibatinibSanofiApprovedPRMT5PI3Ki
SNY-9073SanofiPhase 2B7-H3RAS(ON)i
NVO-7840Novo NordiskPhase 2/3B7-H3GLP-1ag