← Pipeline|JOH-IIT-455

JOH-IIT-455

Approved
Source: Trial-derived·Trials: 1
Modality
mRNA
MOA
BCL-2i
Target
CDK4/6
Pathway
Cell Cycle
Huntington's
Development Pipeline
Preclinical
~Jan 2018
~Apr 2019
Phase 1
~Jul 2019
~Oct 2020
Phase 2
~Jan 2021
~Apr 2022
Phase 3
~Jul 2022
~Oct 2023
NDA/BLA
~Jan 2024
~Apr 2025
Approved
Jul 2025
Jul 2027
ApprovedCurrent
NCT07024869
668 pts·Huntington's
2025-072027-07·Completed
668 total pts1 indication
CompletedCurrentUpcoming
Catalysts (1)
2027-07-121.3y awayPh3 Readout· Huntington's
Trial Timeline
Q3Q42026Q2Q3Q42027Q2Q3
Approved
Complet…
Catalysts
Ph3 Readout
2027-07-12 · 1.3y away
Huntington's
Completed|StartCompletionToday
Trials (1)
NCTPhaseIndicationStatusNEP
NCT07024869ApprovedHuntington'sCompleted668MRD
Competitors (10)
DrugCompanyPhaseTargetMOA
PFE-5501PfizerPhase 1BTKBCL-2i
RHH-3592RochePhase 1/2GIP-RBCL-2i
GeliderotideNovartisNDA/BLAIL-17ABCL-2i
TezecilimabTakedaNDA/BLATauBCL-2i
RimaosocimabAmgenPreclinicalFXIaBCL-2i
MotavorutinibAmgenPhase 3CDK4/6JAK1/2i
RibozanubrutinibRegeneronPhase 1CDK4/6IL-13i
MRN-5715ModernaNDA/BLACDK4/6AuroraAi
CapifutibatinibIncytePhase 3PCSK9BCL-2i
NBI-408NeurocrinePhase 2/3KRASG12DBCL-2i