← Pipeline|NCI-IIT-252

NCI-IIT-252

Approved
By NCI
Source: Trial-derived·Trials: 1
Modality
Gene Editing
MOA
TNFi
Target
RET
Pathway
Amyloid
FTD
Development Pipeline
Preclinical
~May 2016
~Aug 2017
Phase 1
~Nov 2017
~Feb 2019
Phase 2
~May 2019
~Aug 2020
Phase 3
~Nov 2020
~Feb 2022
NDA/BLA
~May 2022
~Aug 2023
Approved
Nov 2023
May 2025
ApprovedCurrent
NCT03340265
297 pts·FTD
2023-112025-05·Recruiting
297 total pts1 indication
CompletedCurrentUpcoming
Catalysts (1)
2025-05-1011mo agoPh3 Readout· FTD
Trial Timeline
2024Q2Q3Q42025Q2
Approved
Recruit…
Catalysts
Ph3 Readout
2025-05-10 · 11mo ago
FTD
Recruiting|StartCompletionToday
Trials (1)
NCTPhaseIndicationStatusNEP
NCT03340265ApprovedFTDRecruiting297DAS28
Competitors (10)
DrugCompanyPhaseTargetMOA
RHH-5389RochePreclinicalRETSTINGag
FixanesiranAbbViePreclinicalRETJAK1/2i
AZN-7403AstraZenecaPhase 2/3FGFRTNFi
BMY-8678Bristol-Myers SquibbApprovedRETMDM2i
TAK-8262TakedaNDA/BLATauTNFi
TalalemzoparlimabGilead SciencesPhase 1FcRnTNFi
VRT-1576Vertex PharmaPhase 2/3RETSHP2i
ARG-3458ArgenxPreclinicalRETIL-17i
RibozanubrutinibGenmabApprovedGPRC5DTNFi
369-789Hansoh PharmaPhase 3PI3KαTNFi