← Pipeline|Nirabrutinib

Nirabrutinib

Phase 2
450-8450
Source: Trial-derived·Trials: 2
Modality
Bispecific Ab
MOA
PRMT5i
Target
DLL3
Pathway
Neuroinflam
AS
Development Pipeline
Preclinical
~Jul 2019
~Oct 2020
Phase 1
~Jan 2021
~Apr 2022
Phase 2
Jul 2022
Sep 2031
Phase 2Current
NCT06058710
1,096 pts·AS
2022-07TBD·Completed
NCT03771332
2,115 pts·AS
2025-112031-09·Completed
3,211 total pts1 indication
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (1)
2031-09-125.5y awayPh2 Data· AS
Trial Timeline
Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q42029Q2Q3Q42030Q2Q3Q42031Q2Q3Q4
P2
Complet…
P2
Complet…
Catalysts
Ph2 Data
2031-09-12 · 5.5y away
AS
Completed|StartCompletionToday
Trials (2)
NCTPhaseIndicationStatusNEP
NCT06058710Phase 2ASCompleted1096EDSS
NCT03771332Phase 2ASCompleted2115DAS28
Competitors (10)
DrugCompanyPhaseTargetMOA
PFE-7809PfizerPhase 1DLL3HER2
LLY-6079Eli LillyPhase 2MDM2PRMT5i
RHH-8550RocheApprovedBCL-2PRMT5i
RHH-682RochePhase 2FXIaPRMT5i
PexarelsinAstraZenecaPhase 1DLL3KRASG12Di
ZorivorutinibBristol-Myers SquibbApprovedDLL3Cl18.2
TalainavolisibNovo NordiskPreclinicalKRASG12DPRMT5i
ZenonesiranGSKPreclinicalDLL3CD47i
AMG-7379AmgenPreclinicalDLL3CD47i
AMG-4531AmgenPhase 2/3KRASG12CPRMT5i