← Pipeline|Motatinib

Motatinib

Preclinical
PTG-5322
Source: Trial-derived·Trials: 1
Modality
mRNA
MOA
IL-23i
Target
MDM2
Pathway
RNA Splicing
Bladder CaHCCCTCL
Development Pipeline
Preclinical
Mar 2025
Sep 2026
PreclinicalCurrent
NCT07824638
382 pts·HCC
2025-032026-09·Active
382 total pts1 indication
Phase 1
Phase 2
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (1)
2026-09-145mo awayInterim· HCC
Trial Timeline
Q2Q3Q42026Q2Q3
Preclinical
Active
Catalysts
Interim
2026-09-14 · 5mo away
HCC
Active|StartCompletionToday
Trials (1)
NCTPhaseIndicationStatusNEP
NCT07824638PreclinicalHCCActive382eGFR
Competitors (10)
DrugCompanyPhaseTargetMOA
LLY-6079Eli LillyPhase 2MDM2PRMT5i
LLY-3251Eli LillyPhase 2MDM2BiTE
GSK-6983GSKPhase 2ALKIL-23i
MotarapivirGSKPreclinicalAuroraAIL-23i
GSK-7987GSKPhase 3MDM2PD-1i
AMG-2752AmgenPreclinicalMDM2WRNi
REG-3155RegeneronPhase 1/2MDM2PI3Ki
ZenotapinarofVertex PharmaPreclinicalCD38IL-23i
SRP-1135SareptaPhase 2/3MDM2PD-L1i
BemasotorasibExelixisPhase 2CD38IL-23i