← Pipeline|AVT-8949

AVT-8949

Phase 3
Source: Trial-derived·Trials: 1
Modality
Radioligand
MOA
KRASG12Di
Target
KRASG12C
Pathway
T-cell
PAHAngelman
Development Pipeline
Preclinical
~Jan 2013
~Apr 2014
Phase 1
~Jul 2014
~Oct 2015
Phase 2
~Jan 2016
~Apr 2017
Phase 3
Jul 2017
Jun 2030
Phase 3Current
NCT03550049
2,660 pts·Angelman
2017-072030-06·Recruiting
2,660 total pts1 indication
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (1)
2030-06-124.2y awayPh3 Readout· Angelman
Trial Timeline
Q2Q3Q42018Q2Q3Q42019Q2Q3Q42020Q2Q3Q42021Q2Q3Q42022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q42029Q2Q3Q42030Q2Q3
P3
Recruit…
Catalysts
Ph3 Readout
2030-06-12 · 4.2y away
Angelman
Recruiting|StartCompletionToday
Trials (1)
NCTPhaseIndicationStatusNEP
NCT03550049Phase 3AngelmanRecruiting2660DOR
Competitors (10)
DrugCompanyPhaseTargetMOA
JNJ-179Johnson & JohnsonApprovedKRASG12CBETi
DoxarasimodMerck & CoNDA/BLAFGFRKRASG12Di
ZanusertibAbbVieApprovedPCSK9KRASG12Di
PexarelsinAstraZenecaPhase 1DLL3KRASG12Di
BMY-4586Bristol-Myers SquibbPreclinicalKRASG12CIL-13i
DoxarapivirBristol-Myers SquibbPhase 3KRASG12CSOS1i
IvotuximabGSKNDA/BLAGIP-RKRASG12Di
AMG-4531AmgenPhase 2/3KRASG12CPRMT5i
REG-8074RegeneronPhase 2/3KRASG12CCAR-T BCMA
VRT-1891Vertex PharmaPhase 1KRASG12CPRMT5i