← Pipeline|Semacapivasertib

Semacapivasertib

Preclinical
600-4200
Source: Trial-derived·Trials: 2
Modality
ASO
MOA
Cl18.2
Target
CDK4/6
Pathway
PI3K/AKT
RBAMLBreast Ca
Development Pipeline
Preclinical
May 2025
Sep 2031
PreclinicalCurrent
NCT07622695
52 pts·Breast Ca
2025-102031-09·Completed
NCT05547109
1,396 pts·Breast Ca
2025-052030-08·Active
1,448 total pts1 indication
Phase 1
Phase 2
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (2)
2030-08-044.3y awayInterim· Breast Ca
2031-09-075.4y awayInterim· Breast Ca
Trial Timeline
Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q42029Q2Q3Q42030Q2Q3Q42031Q2Q3Q4
Preclinical
Active
Preclinical
Complet…
Catalysts
Interim
2030-08-04 · 4.3y away
Breast Ca
Interim
2031-09-07 · 5.4y away
Breast Ca
ActiveCompleted|StartCompletionToday
Trials (2)
NCTPhaseIndicationStatusNEP
NCT07622695PreclinicalBreast CaCompleted52ACR20
NCT05547109PreclinicalBreast CaActive13966MWD
Competitors (10)
DrugCompanyPhaseTargetMOA
ZorivorutinibBristol-Myers SquibbApprovedDLL3Cl18.2
MotavorutinibAmgenPhase 3CDK4/6JAK1/2i
RibozanubrutinibRegeneronPhase 1CDK4/6IL-13i
ElrarapivirRegeneronPhase 1GIP-RCl18.2
MRN-5715ModernaNDA/BLACDK4/6AuroraAi
HAL-9635HalozymePhase 2/3EZH2Cl18.2
VKT-6548Viking TherapeuticsPhase 2/3PD-L1Cl18.2
TiratapinarofIntelliaNDA/BLAAPOC3Cl18.2
ElralucimabAxsomePhase 2CDK4/6MDM2i
ELV-1411EnlivenNDA/BLAHER2Cl18.2