← Pipeline|Nidanesiran

Nidanesiran

Preclinical
LIO-2443
Source: Trial-derived·Trials: 1
Modality
Gene Editing
MOA
SOS1i
Target
RET
Pathway
Incretin
HNSCCTTR Amyloidosis
Development Pipeline
Preclinical
Aug 2019
Aug 2028
PreclinicalCurrent
NCT06629520
890 pts·TTR Amyloidosis
2019-082028-08·Terminated
890 total pts1 indication
Phase 1
Phase 2
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (1)
2028-08-112.4y awayInterim· TTR Amyloidosis
Trial Timeline
Q3Q42020Q2Q3Q42021Q2Q3Q42022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q4
Preclinical
Termina…
Catalysts
Interim
2028-08-11 · 2.4y away
TTR Amyloidosis
Terminated|StartCompletionToday
Trials (1)
NCTPhaseIndicationStatusNEP
NCT06629520PreclinicalTTR AmyloidosisTerminated890NT-proBNP
Competitors (10)
DrugCompanyPhaseTargetMOA
PFE-2901PfizerPhase 2AHRSOS1i
RHH-5389RochePreclinicalRETSTINGag
MRK-1380Merck & CoPreclinicalSHP2SOS1i
FixanesiranAbbViePreclinicalRETJAK1/2i
TerarelsinAbbViePreclinicalSOS1SOS1i
BMY-8678Bristol-Myers SquibbApprovedRETMDM2i
DoxarapivirBristol-Myers SquibbPhase 3KRASG12CSOS1i
DSN-6862Daiichi SankyoPreclinicalIL-23SOS1i
GIL-2011Gilead SciencesPreclinicalVEGFSOS1i
REG-647RegeneronPreclinicalSMN2SOS1i