← Pipeline|Daranesiran

Daranesiran

Preclinical
RIC-9120
Source: Trial-derived·Trials: 2
Modality
siRNA
MOA
KIF18Ai
Target
IL-23
Pathway
Neuroinflam
ALSWet AMDBreast Ca
Development Pipeline
Preclinical
Jul 2018
Aug 2031
PreclinicalCurrent
NCT06600571
944 pts·Breast Ca
2024-112031-08·Active
NCT05387238
2,894 pts·ALS
2018-072026-08·Completed
3,838 total pts2 indications
Phase 1
Phase 2
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (2)
2026-08-215mo awayInterim· ALS
2031-08-235.4y awayInterim· Breast Ca
Trial Timeline
Q2Q3Q42019Q2Q3Q42020Q2Q3Q42021Q2Q3Q42022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q42029Q2Q3Q42030Q2Q3Q42031Q2Q3Q4
Preclinical
Complet…
Preclinical
Active
Catalysts
Interim
2026-08-21 · 5mo away
ALS
Interim
2031-08-23 · 5.4y away
Breast Ca
ActiveCompleted|StartCompletionToday
Trials (2)
NCTPhaseIndicationStatusNEP
NCT06600571PreclinicalBreast CaActive944MRD
NCT05387238PreclinicalALSCompleted2894ACR20
Competitors (10)
DrugCompanyPhaseTargetMOA
PFE-7550PfizerPhase 3KIF18Ai
RibosacituzumabRocheApprovedCl18.2KIF18Ai
RHH-8482RochePhase 1BTKKIF18Ai
PexatenlimabNovartisPhase 1/2GPRC5DKIF18Ai
MRK-7739Merck & CoPreclinicalIL-23ALKi
TerasacituzumabNovo NordiskNDA/BLAIL-23KRASG12Ci
TAK-1836TakedaPreclinicalEGFRKIF18Ai
DSN-6862Daiichi SankyoPreclinicalIL-23SOS1i
TezecilimabRegeneronApprovedIL-23CGRPant
FixaglumideGenmabPhase 2/3WEE1KIF18Ai