← Pipeline|MIR-8412

MIR-8412

Phase 1/2
Source: Trial-derived·Trials: 1
Modality
ADC
MOA
KRASG12Di
Target
APOC3
Pathway
Cell Cycle
OCDEndometrial Ca
Development Pipeline
Preclinical
~Dec 2022
~Mar 2024
Phase 1
Jun 2024
Jul 2027
Phase 1Current
NCT04048732
208 pts·Endometrial Ca
2024-062027-07·Recruiting
208 total pts1 indication
Phase 2
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (1)
2027-07-151.3y awayPh2 Data· Endometrial Ca
Trial Timeline
Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3
P1/2
Recruit…
Catalysts
Ph2 Data
2027-07-15 · 1.3y away
Endometrial Ca
Recruiting|StartCompletionToday
Trials (1)
NCTPhaseIndicationStatusNEP
NCT04048732Phase 1/2Endometrial CaRecruiting208Biomarker
Competitors (10)
DrugCompanyPhaseTargetMOA
PFE-1944PfizerNDA/BLAAPOC3HPK1i
DoxacapivasertibEli LillyPhase 3APOC3MDM2i
DoxarasimodMerck & CoNDA/BLAFGFRKRASG12Di
ZanusertibAbbVieApprovedPCSK9KRASG12Di
PexarelsinAstraZenecaPhase 1DLL3KRASG12Di
AZN-6294AstraZenecaPhase 2/3APOC3CD47i
ZanutinibBristol-Myers SquibbPhase 2/3APOC3BiTE
IvotuximabGSKNDA/BLAGIP-RKRASG12Di
ALN-5628AlnylamPhase 1/2APOC3SGLT2i
INC-1582IncytePhase 1/2APOC3TROP-2 ADC