← Pipeline|Sematuximab

Sematuximab

Phase 2/3
AFM-3975
Source: Trial-derived·Trials: 2
Modality
Vaccine
MOA
KRASG12Ci
Target
FXIa
Pathway
Wnt
MyelofibrosisPsANSCLC
Development Pipeline
Preclinical
~Feb 2015
~May 2016
Phase 1
~Aug 2016
~Nov 2017
Phase 2
Feb 2018
Jul 2030
Phase 2Current
NCT06084329
1,860 pts·NSCLC
2020-062030-07·Terminated
NCT05694939
651 pts·NSCLC
2018-022029-04·Recruiting
2,511 total pts1 indication
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (2)
2029-04-143.0y awayPh3 Readout· NSCLC
2030-07-144.3y awayPh3 Readout· NSCLC
Trial Timeline
2018Q2Q3Q42019Q2Q3Q42020Q2Q3Q42021Q2Q3Q42022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q42029Q2Q3Q42030Q2Q3Q4
P2/3
Recruit…
P2/3
Termina…
Catalysts
Ph3 Readout
2029-04-14 · 3.0y away
NSCLC
Ph3 Readout
2030-07-14 · 4.3y away
NSCLC
RecruitingTerminated|StartCompletionToday
Trials (2)
NCTPhaseIndicationStatusNEP
NCT06084329Phase 2/3NSCLCTerminated1860PANSS
NCT05694939Phase 2/3NSCLCRecruiting651ACR20
Competitors (10)
DrugCompanyPhaseTargetMOA
PFE-1085PfizerPreclinicalFXIaPD-L1i
RHH-682RochePhase 2FXIaPRMT5i
RHH-7975RochePhase 3FXIaIL-13i
LisolucimabNovartisApprovedCD20KRASG12Ci
GozelemzoparlimabMerck & CoPhase 2FXIaKRASG12Ci
AZN-8478AstraZenecaNDA/BLASHP2KRASG12Ci
PexazasiranSanofiPreclinicalFXIaKRASG12Ci
TerasacituzumabNovo NordiskNDA/BLAIL-23KRASG12Ci
RimaosocimabAmgenPreclinicalFXIaBCL-2i
GIL-9142Gilead SciencesPhase 1FXIaPRMT5i