← Pipeline|AMG-4531

AMG-4531

Phase 2/3
Source: Trial-derived·Trials: 2
Modality
Vaccine
MOA
PRMT5i
Target
KRASG12C
Pathway
JAK/STAT
CLL
Development Pipeline
Preclinical
~Jan 2014
~Apr 2015
Phase 1
~Jul 2015
~Oct 2016
Phase 2
Jan 2017
Jun 2030
Phase 2Current
NCT03951302
2,090 pts·CLL
2018-022030-06·Recruiting
NCT03742985
885 pts·CLL
2017-012025-03·Active
2,975 total pts1 indication
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (2)
2025-03-211.0y agoPh3 Readout· CLL
2030-06-184.2y awayPh3 Readout· CLL
Trial Timeline
2017Q2Q3Q42018Q2Q3Q42019Q2Q3Q42020Q2Q3Q42021Q2Q3Q42022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q42029Q2Q3Q42030Q2Q3
P2/3
Active
P2/3
Recruit…
Catalysts
Ph3 Readout
2025-03-21 · 1.0y ago
CLL
Ph3 Readout
2030-06-18 · 4.2y away
CLL
RecruitingActive|StartCompletionToday
Trials (2)
NCTPhaseIndicationStatusNEP
NCT03951302Phase 2/3CLLRecruiting2090LiverFat
NCT03742985Phase 2/3CLLActive885LiverFat
Competitors (10)
DrugCompanyPhaseTargetMOA
JNJ-179Johnson & JohnsonApprovedKRASG12CBETi
LLY-6079Eli LillyPhase 2MDM2PRMT5i
RHH-8550RocheApprovedBCL-2PRMT5i
RHH-682RochePhase 2FXIaPRMT5i
BMY-4586Bristol-Myers SquibbPreclinicalKRASG12CIL-13i
DoxarapivirBristol-Myers SquibbPhase 3KRASG12CSOS1i
TalainavolisibNovo NordiskPreclinicalKRASG12DPRMT5i
GIL-9142Gilead SciencesPhase 1FXIaPRMT5i
SemainavolisibGilead SciencesPhase 2PARPPRMT5i
REG-8074RegeneronPhase 2/3KRASG12CCAR-T BCMA