← Pipeline|Semasertib

Semasertib

Phase 2
TAR-7476
Source: Trial-derived·Trials: 2
Modality
ADC
MOA
GLP-1/GIP
Target
HER2
Pathway
RAS/MAPK
ALSUC
Development Pipeline
Preclinical
~Oct 2015
~Jan 2017
Phase 1
~Apr 2017
~Jul 2018
Phase 2
Oct 2018
May 2027
Phase 2Current
NCT08171169
701 pts·ALS
2023-112026-10·Active
NCT05971103
23 pts·UC
2018-102027-05·Not yet recruiting
724 total pts2 indications
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (2)
2026-10-207mo awayPh2 Data· ALS
2027-05-071.1y awayPh2 Data· UC
Trial Timeline
Q42019Q2Q3Q42020Q2Q3Q42021Q2Q3Q42022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3
P2
Not yet…
P2
Active
Catalysts
Ph2 Data
2026-10-20 · 7mo away
ALS
Ph2 Data
2027-05-07 · 1.1y away
UC
ActiveNot yet recruiting|StartCompletionToday
Trials (2)
NCTPhaseIndicationStatusNEP
NCT08171169Phase 2ALSActive701HAM-D
NCT05971103Phase 2UCNot yet recr...23CR
Competitors (10)
DrugCompanyPhaseTargetMOA
ZanuderotideJohnson & JohnsonPhase 2/3TIGITGLP-1/GIP
JNJ-8168Johnson & JohnsonPhase 2/3FLT3GLP-1/GIP
AZN-5171AstraZenecaApprovedGLP-1RGLP-1/GIP
GozesotorasibBristol-Myers SquibbNDA/BLAHER2IL-13i
VRT-4938Vertex PharmaPreclinicalHER2CDK4/6i
PemiinavolisibSareptaNDA/BLACD47GLP-1/GIP
ROI-9675Roivant SciencesNDA/BLAHER2USP1i
BEA-4274BeamPhase 1/2ALKGLP-1/GIP
ELV-1411EnlivenNDA/BLAHER2Cl18.2
PST-2276PoseidaApprovedGLP-1/GIP