← Pipeline|EVO-481

EVO-481

Preclinical
Source: Trial-derived·Trials: 1
Modality
Radioligand
MOA
CDK4/6i
Target
JAK1
Pathway
mTOR
Schizophrenia
Development Pipeline
Preclinical
Jun 2020
Feb 2028
PreclinicalCurrent
NCT04427637
658 pts·Schizophrenia
2020-062028-02·Terminated
658 total pts1 indication
Phase 1
Phase 2
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (1)
2028-02-031.8y awayInterim· Schizophrenia
Trial Timeline
Q3Q42021Q2Q3Q42022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028
Preclinical
Termina…
Catalysts
Interim
2028-02-03 · 1.8y away
Schizophrenia
Terminated|StartCompletionToday
Trials (1)
NCTPhaseIndicationStatusNEP
NCT04427637PreclinicalSchizophreniaTerminated658HAM-D
Competitors (10)
DrugCompanyPhaseTargetMOA
PFE-5767PfizerPhase 1/2BETCDK4/6i
IvorelsinEli LillyApprovedJAK1Menini
RHH-1969RocheApprovedBETCDK4/6i
RHH-974RochePreclinicalJAK1MALT1i
IvocapivasertibBristol-Myers SquibbPhase 1BETCDK4/6i
ZorimavacamtenBristol-Myers SquibbPreclinicalCl18.2CDK4/6i
FixatenlimabGSKPhase 1/2JAK1CDK4/6i
GIL-8529Gilead SciencesPhase 1/2JAK1EGFRi
VRT-4938Vertex PharmaPreclinicalHER2CDK4/6i
VRT-5441Vertex PharmaPhase 3GLP-1RCDK4/6i