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← Pipeline|Semalemzoparlimab

Semalemzoparlimab

Phase 3
PRI-3145
By Principia (Sanofi)
Source: Trial-derived·Trials: 4
Modality
Vaccine
MOA
SOS1i
Target
EGFR
Pathway
Hedgehog
Huntington's
Development Pipeline
Preclinical
~Jul 2014
→ ~Oct 2015
Phase 1
~Jan 2016
→ ~Apr 2017
Phase 2
~Jul 2017
→ ~Oct 2018
Phase 3
Jan 2019
→ Dec 2031
Phase 3Current
NCT08750550
1,766 pts·Huntington's
2023-01→2025-07·Terminated
NCT06519049
2,160 pts·Huntington's
2023-04→2031-12·Not yet recruiting
NCT03188033
2,287 pts·Huntington's
2021-08→2028-11·Recruiting
+1 more trial
6,228 total pts1 indication
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (4)
2025-07-159mo agoPh3 Readout· Huntington's
2028-08-042.3y awayPh3 Readout· Huntington's
2028-11-262.7y awayPh3 Readout· Huntington's
2031-12-065.7y awayPh3 Readout· Huntington's
Trial Timeline
2019Q2Q3Q42020Q2Q3Q42021Q2Q3Q42022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q42029Q2Q3Q42030Q2Q3Q42031Q2Q3Q4
P3
Complet…
P3
Recruit…
P3
Termina…
P3
Not yet…
Catalysts
Ph3 Readout
2025-07-15 · 9mo ago
Huntington's
Ph3 Readout
2028-08-04 · 2.3y away
Huntington's
Ph3 Readout
2028-11-26 · 2.7y away
Huntington's
Ph3 Readout
2031-12-06 · 5.7y away
Huntington's
RecruitingCompletedTerminatedNot yet recruiting|StartCompletionToday
Trials (4)
NCTPhaseIndicationStatusNEP
NCT08750550Phase 3Huntington'sTerminated1766ORR
NCT06519049Phase 3Huntington'sNot yet recr...2160SeizFreq
NCT03188033Phase 3Huntington'sRecruiting2287ACR20
NCT06565395Phase 3Huntington'sCompleted15EDSS
Competitors (10)
DrugCompanyPhaseTargetMOA
PFE-2901PfizerPhase 2AHRSOS1i
MRK-1380Merck & CoPreclinicalSHP2SOS1i
TerarelsinAbbViePreclinicalSOS1SOS1i
AZN-6870AstraZenecaPhase 2/3EGFRCDK2i
DoxarapivirBristol-Myers SquibbPhase 3KRASG12CSOS1i
TAK-1836TakedaPreclinicalEGFRKIF18Ai
DSN-6862Daiichi SankyoPreclinicalIL-23SOS1i
GIL-2011Gilead SciencesPreclinicalVEGFSOS1i
REG-647RegeneronPreclinicalSMN2SOS1i
CevisacituzumabAlnylamPreclinicalMALT1SOS1i