← Pipeline|Talafotisoran

Talafotisoran

Phase 1
PRI-8249
Source: Trial-derived·Trials: 1
Modality
ASO
MOA
PRMT5i
Target
USP1
Pathway
Complement
Melanoma
Development Pipeline
Preclinical
~Sep 2019
~Dec 2020
Phase 1
Mar 2021
Jan 2026
Phase 1Current
NCT08530078
2,330 pts·Melanoma
2021-032026-01·Terminated
2,330 total pts1 indication
Phase 2
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (2)
2026-01-192mo agoInterim· Melanoma
2026-12-289mo awayPDUFA· Melanoma
Trial Timeline
Q2Q3Q42022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q4
P1
Termina…
Catalysts
Interim
2026-01-19 · 2mo ago
Melanoma
PDUFA
2026-12-28 · 9mo away
Melanoma
Terminated|StartCompletionToday
Trials (1)
NCTPhaseIndicationStatusNEP
NCT08530078Phase 1MelanomaTerminated2330SRI-4
Competitors (10)
DrugCompanyPhaseTargetMOA
LLY-6079Eli LillyPhase 2MDM2PRMT5i
RHH-8550RocheApprovedBCL-2PRMT5i
RHH-682RochePhase 2FXIaPRMT5i
ABB-2476AbbViePhase 1/2USP1FcRni
TalainavolisibNovo NordiskPreclinicalKRASG12DPRMT5i
AMG-4531AmgenPhase 2/3KRASG12CPRMT5i
GIL-9142Gilead SciencesPhase 1FXIaPRMT5i
SemainavolisibGilead SciencesPhase 2PARPPRMT5i
VRT-1891Vertex PharmaPhase 1KRASG12CPRMT5i
ASN-4879Ascendis PharmaPhase 3CGRPPRMT5i