← Pipeline|Lirainavolisib

Lirainavolisib

Preclinical
ZBI-5761
Source: Trial-derived·Trials: 2
Modality
Nanobody
MOA
USP1i
Target
TIGIT
Pathway
Epigenetic
FTDPsoriasis
Development Pipeline
Preclinical
May 2020
Dec 2028
PreclinicalCurrent
NCT07483615
2,110 pts·FTD
2022-122025-11·Not yet recruiting
NCT04074394
1,983 pts·Psoriasis
2020-052028-12·Not yet recruiting
4,093 total pts2 indications
Phase 1
Phase 2
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (3)
2025-10-195mo agoNDA· FTD
2025-11-254mo agoInterim· FTD
2028-12-252.7y awayInterim· Psoriasis
Trial Timeline
Q2Q3Q42021Q2Q3Q42022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q4
Preclinical
Not yet…
Preclinical
Not yet…
Catalysts
NDA
2025-10-19 · 5mo ago
FTD
Interim
2025-11-25 · 4mo ago
FTD
Interim
2028-12-25 · 2.7y away
Psoriasis
Not yet recruiting|StartCompletionToday
Trials (2)
NCTPhaseIndicationStatusNEP
NCT07483615PreclinicalFTDNot yet recr...2110NT-proBNP
NCT04074394PreclinicalPsoriasisNot yet recr...1983DAS28
Competitors (10)
DrugCompanyPhaseTargetMOA
ZanuderotideJohnson & JohnsonPhase 2/3TIGITGLP-1/GIP
MRK-6781Merck & CoApprovedTIGITRAS(ON)i
SNY-2934SanofiPhase 3KRASG12DUSP1i
PexamavacamtenDaiichi SankyoNDA/BLATIGITCD3xCD20
AMG-9052AmgenPhase 2/3CDK2USP1i
DatozumabRegeneronPhase 1B7-H3USP1i
BNT-5232BioNTechNDA/BLATIGITPARPi
ALN-8757AlnylamPreclinicalTIGITCFTRmod
GMA-729GenmabPhase 2BCL-2USP1i
MiritinibNeurocrinePhase 3TIGITSTINGag