← Pipeline|Motavorutinib

Motavorutinib

NDA/BLA
AFF-9229
Source: Trial-derived·Trials: 2
Modality
Fusion Protein
MOA
CAR-T BCMA
Target
PRMT5
Pathway
Checkpoint
WMWet AMD
Development Pipeline
Preclinical
~Mar 2018
~Jun 2019
Phase 1
~Sep 2019
~Dec 2020
Phase 2
~Mar 2021
~Jun 2022
Phase 3
~Sep 2022
~Dec 2023
NDA/BLA
Mar 2024
Aug 2026
NDA/BLACurrent
NCT06890104
1,759 pts·Wet AMD
2025-042026-08·Not yet recruiting
NCT07627218
2,789 pts·Wet AMD
2024-032025-12·Recruiting
4,548 total pts1 indication
Approved
CompletedCurrentUpcoming
Catalysts (2)
2025-12-283mo agoPh3 Readout· Wet AMD
2026-08-074mo awayPh3 Readout· Wet AMD
Trial Timeline
Q2Q3Q42025Q2Q3Q42026Q2Q3
NDA/BLA
Recruit…
NDA/BLA
Not yet…
Catalysts
Ph3 Readout
2025-12-28 · 3mo ago
Wet AMD
Ph3 Readout
2026-08-07 · 4mo away
Wet AMD
RecruitingNot yet recruiting|StartCompletionToday
Trials (2)
NCTPhaseIndicationStatusNEP
NCT06890104NDA/BLAWet AMDNot yet recr...1759PFS
NCT07627218NDA/BLAWet AMDRecruiting2789EDSS
Competitors (10)
DrugCompanyPhaseTargetMOA
VoxacilimabPfizerPhase 2TYK2CAR-T BCMA
NirarelsinJohnson & JohnsonPhase 2PRMT5CD47i
MRK-853Merck & CoPhase 1PRMT5WEE1i
GeliderotideSanofiPhase 1/2PRMT5JAK1i
CapifutibatinibSanofiApprovedPRMT5PI3Ki
NVO-9087Novo NordiskPhase 1/2TauCAR-T BCMA
NVO-9615Novo NordiskPhase 2/3PRMT5EZH2i
SuracageneGSKPhase 3PRMT5FcRni
FixazanubrutinibAmgenPhase 2PI3KαCAR-T BCMA
REG-8074RegeneronPhase 2/3KRASG12CCAR-T BCMA