← Pipeline|NCI-IIT-143

NCI-IIT-143

Phase 1/2
By NCI
Source: Trial-derived·Trials: 1
Modality
Small Molecule
MOA
PCSK9i
Target
HER2
Pathway
Autophagy
ALL
Development Pipeline
Preclinical
~May 2022
~Aug 2023
Phase 1
Nov 2023
May 2025
Phase 1Current
NCT05946323
298 pts·ALL
2023-112025-05·Active
298 total pts1 indication
Phase 2
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (2)
2025-05-0711mo agoPh2 Data· ALL
2026-10-247mo awayBTD· ALL
Trial Timeline
2024Q2Q3Q42025Q2Q3Q42026Q2Q3Q4
P1/2
Active
Catalysts
Ph2 Data
2025-05-07 · 11mo ago
ALL
BTD
2026-10-24 · 7mo away
ALL
Active|StartCompletionToday
Trials (1)
NCTPhaseIndicationStatusNEP
NCT05946323Phase 1/2ALLActive298EFS
Competitors (10)
DrugCompanyPhaseTargetMOA
MRK-8368Merck & CoPhase 3ALKPCSK9i
RibofutibatinibAstraZenecaPhase 2/3SOS1PCSK9i
AZN-4015AstraZenecaPreclinicalBCMAPCSK9i
GozesotorasibBristol-Myers SquibbNDA/BLAHER2IL-13i
PolazasiranAmgenPhase 2LAG-3PCSK9i
CevitinibRegeneronPhase 3FGFRPCSK9i
VRT-4938Vertex PharmaPreclinicalHER2CDK4/6i
INC-1261IncytePhase 1/2PRMT5PCSK9i
MavutuximabHansoh PharmaPhase 2/3PI3KαPCSK9i
ROI-9675Roivant SciencesNDA/BLAHER2USP1i