← Pipeline|Rilunesiran

Rilunesiran

Phase 1/2
APG-5875
Source: Trial-derived·Trials: 2
Modality
Cell Therapy
MOA
SHP2i
Target
GPRC5D
Pathway
Proteasome
GA
Development Pipeline
Preclinical
~Dec 2022
~Mar 2024
Phase 1
Jun 2024
Jul 2030
Phase 1Current
NCT07193676
423 pts·GA
2024-112027-06·Terminated
NCT04625722
953 pts·GA
2024-062030-07·Completed
1,376 total pts1 indication
Phase 2
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (2)
2027-06-141.2y awayPh2 Data· GA
2030-07-204.3y awayPh2 Data· GA
Trial Timeline
Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q42029Q2Q3Q42030Q2Q3
P1/2
Complet…
P1/2
Termina…
Catalysts
Ph2 Data
2027-06-14 · 1.2y away
GA
Ph2 Data
2030-07-20 · 4.3y away
GA
CompletedTerminated|StartCompletionToday
Trials (2)
NCTPhaseIndicationStatusNEP
NCT07193676Phase 1/2GATerminated423PASI75
NCT04625722Phase 1/2GACompleted953SeizFreq
Competitors (10)
DrugCompanyPhaseTargetMOA
PFE-2191PfizerNDA/BLAGLP-1RSHP2i
PexatenlimabNovartisPhase 1/2GPRC5DKIF18Ai
RibotuximabMerck & CoPhase 2GPRC5DEZH2i
BMY-9931Bristol-Myers SquibbPhase 1GPRC5DFXIai
DoxacageneSanofiApprovedPSMASHP2i
NVO-7877Novo NordiskPreclinicalGPRC5DFXIai
AMG-9654AmgenPhase 2GPRC5DDLL3 ADC
GIL-9227Gilead SciencesPhase 2/3GPRC5DCDK2i
VRT-1576Vertex PharmaPhase 2/3RETSHP2i
SovafutibatinibModernaApprovedFcRnSHP2i