← Pipeline|Sematapinarof

Sematapinarof

NDA/BLA
LEG-5243
Source: Trial-derived·Trials: 1
Modality
Fusion Protein
MOA
CGRPant
Target
VEGF
Pathway
Wnt
MDDSCDNSCLC
Development Pipeline
Preclinical
~Oct 2016
~Jan 2018
Phase 1
~Apr 2018
~Jul 2019
Phase 2
~Oct 2019
~Jan 2021
Phase 3
~Apr 2021
~Jul 2022
NDA/BLA
Oct 2022
Nov 2031
NDA/BLACurrent
NCT07636934
994 pts·NSCLC
2022-102031-11·Completed
994 total pts1 indication
Approved
CompletedCurrentUpcoming
Catalysts (1)
2031-11-165.6y awayPh3 Readout· NSCLC
Trial Timeline
Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q42029Q2Q3Q42030Q2Q3Q42031Q2Q3Q4
NDA/BLA
Complet…
Catalysts
Ph3 Readout
2031-11-16 · 5.6y away
NSCLC
Completed|StartCompletionToday
Trials (1)
NCTPhaseIndicationStatusNEP
NCT07636934NDA/BLANSCLCCompleted994BodyWt
Competitors (10)
DrugCompanyPhaseTargetMOA
TerafutibatinibPfizerPhase 1/2CD38CGRPant
SotovorutinibPfizerApprovedCGRPant
ZanuderotideNovartisPhase 1/2VEGFCD3xCD20
ABB-3060AbbViePhase 2LAG-3CGRPant
TAK-8730TakedaPhase 2VEGFFXIai
GIL-2011Gilead SciencesPreclinicalVEGFSOS1i
GIL-6239Gilead SciencesPhase 2TNFαCGRPant
BemazumabRegeneronPhase 1VEGFTROP-2 ADC
TezecilimabRegeneronApprovedIL-23CGRPant
INC-2432IncytePhase 2CD47CGRPant