← Pipeline|GR-8075

GR-8075

Preclinical
Source: Trial-derived·Trials: 2
Modality
Cell Therapy
MOA
CD3xCD20
Target
KRASG12C
Pathway
Apoptosis
RettHCC
Development Pipeline
Preclinical
Apr 2018
Jul 2031
PreclinicalCurrent
NCT06607755
2,538 pts·HCC
2018-042031-07·Recruiting
NCT07329646
994 pts·Rett
2025-092029-03·Active
3,532 total pts2 indications
Phase 1
Phase 2
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (2)
2029-03-072.9y awayInterim· Rett
2031-07-195.3y awayInterim· HCC
Trial Timeline
2018Q2Q3Q42019Q2Q3Q42020Q2Q3Q42021Q2Q3Q42022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q42029Q2Q3Q42030Q2Q3Q42031Q2Q3Q4
Preclinical
Recruit…
Preclinical
Active
Catalysts
Interim
2029-03-07 · 2.9y away
Rett
Interim
2031-07-19 · 5.3y away
HCC
RecruitingActive|StartCompletionToday
Trials (2)
NCTPhaseIndicationStatusNEP
NCT06607755PreclinicalHCCRecruiting25386MWD
NCT07329646PreclinicalRettActive994OS
Competitors (10)
DrugCompanyPhaseTargetMOA
JNJ-179Johnson & JohnsonApprovedKRASG12CBETi
LLY-1184Eli LillyNDA/BLAC5CD3xCD20
ZanuderotideNovartisPhase 1/2VEGFCD3xCD20
BMY-4586Bristol-Myers SquibbPreclinicalKRASG12CIL-13i
DoxarapivirBristol-Myers SquibbPhase 3KRASG12CSOS1i
NVO-1361Novo NordiskPhase 3CD38CD3xCD20
ZorizanubrutinibNovo NordiskPhase 1BTKCD3xCD20
PexamavacamtenDaiichi SankyoNDA/BLATIGITCD3xCD20
AMG-4531AmgenPhase 2/3KRASG12CPRMT5i
REG-8074RegeneronPhase 2/3KRASG12CCAR-T BCMA