← Pipeline|Semalemzoparlimab

Semalemzoparlimab

Phase 1/2
TOL-6648
Source: Trial-derived·Trials: 1
Modality
Gene Editing
MOA
WEE1i
Target
CD47
Pathway
Innate Imm
Wet AMD
Development Pipeline
Preclinical
~Aug 2020
~Nov 2021
Phase 1
Feb 2022
Jul 2026
Phase 1Current
NCT08755735
1,188 pts·Wet AMD
2022-022026-07·Not yet recruiting
1,188 total pts1 indication
Phase 2
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (1)
2026-07-254mo awayPh2 Data· Wet AMD
Trial Timeline
2022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3
P1/2
Not yet…
Catalysts
Ph2 Data
2026-07-25 · 4mo away
Wet AMD
Not yet recruiting|StartCompletionToday
Trials (1)
NCTPhaseIndicationStatusNEP
NCT08755735Phase 1/2Wet AMDNot yet recr...1188HAM-D
Competitors (10)
DrugCompanyPhaseTargetMOA
JNJ-8637Johnson & JohnsonNDA/BLACD20WEE1i
LLY-8903Eli LillyPreclinicalCD47HER2
MRK-853Merck & CoPhase 1PRMT5WEE1i
GSK-4334GSKPreclinicalCD47WRNi
DoxafotisoranDaiichi SankyoPhase 1Cl18.2WEE1i
MotainavolisibAmgenNDA/BLACD47PD-L1i
GMA-1468GenmabNDA/BLAPI3KαWEE1i
BMR-1165BioMarinPhase 2CD47TYK2i
INC-2432IncytePhase 2CD47CGRPant
CevifotisoranNeurocrineApprovedCD47PARPi