← Pipeline|REG-647

REG-647

Preclinical
Source: Trial-derived·Trials: 1
Modality
Gene Therapy
MOA
SOS1i
Target
SMN2
Pathway
Notch
CLLNSCLCRett
Development Pipeline
Preclinical
Apr 2019
Feb 2027
PreclinicalCurrent
NCT05987952
1,361 pts·Rett
2019-042027-02·Active
1,361 total pts1 indication
Phase 1
Phase 2
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (1)
2027-02-0610mo awayInterim· Rett
Trial Timeline
Q2Q3Q42020Q2Q3Q42021Q2Q3Q42022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2
Preclinical
Active
Catalysts
Interim
2027-02-06 · 10mo away
Rett
Active|StartCompletionToday
Trials (1)
NCTPhaseIndicationStatusNEP
NCT05987952PreclinicalRettActive1361Safety
Competitors (10)
DrugCompanyPhaseTargetMOA
PFE-2901PfizerPhase 2AHRSOS1i
MRK-1380Merck & CoPreclinicalSHP2SOS1i
TerarelsinAbbViePreclinicalSOS1SOS1i
DoxarapivirBristol-Myers SquibbPhase 3KRASG12CSOS1i
NVO-6275Novo NordiskPhase 1SMN2BTKi
TAK-5300TakedaPhase 1SMN2AuroraAi
DSN-6862Daiichi SankyoPreclinicalIL-23SOS1i
GIL-2011Gilead SciencesPreclinicalVEGFSOS1i
GIL-2259Gilead SciencesApprovedSMN2CAR-T CD19
CevisacituzumabAlnylamPreclinicalMALT1SOS1i