← Pipeline|Semarasimod

Semarasimod

Phase 1/2
LEN-8766
Source: Trial-derived·Trials: 2
Modality
Nanobody
MOA
CGRPant
Target
EZH2
Pathway
PI3K/AKT
HCCSMAUrothelial Ca
Development Pipeline
Preclinical
~Jun 2021
~Sep 2022
Phase 1
Dec 2022
Nov 2030
Phase 1Current
NCT05744971
44 pts·HCC
2022-122030-11·Terminated
NCT05319394
543 pts·HCC
2024-032027-02·Terminated
587 total pts1 indication
Phase 2
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (2)
2027-02-0810mo awayPh2 Data· HCC
2030-11-284.7y awayPh2 Data· HCC
Trial Timeline
2023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q42029Q2Q3Q42030Q2Q3Q4
P1/2
Termina…
P1/2
Termina…
Catalysts
Ph2 Data
2027-02-08 · 10mo away
HCC
Ph2 Data
2030-11-28 · 4.7y away
HCC
Terminated|StartCompletionToday
Trials (2)
NCTPhaseIndicationStatusNEP
NCT05744971Phase 1/2HCCTerminated44DAS28
NCT05319394Phase 1/2HCCTerminated543UPDRS
Competitors (10)
DrugCompanyPhaseTargetMOA
TerafutibatinibPfizerPhase 1/2CD38CGRPant
SotovorutinibPfizerApprovedCGRPant
ABB-3060AbbViePhase 2LAG-3CGRPant
DSN-2247Daiichi SankyoNDA/BLAEZH2C5i
GIL-6239Gilead SciencesPhase 2TNFαCGRPant
TezecilimabRegeneronApprovedIL-23CGRPant
INC-2432IncytePhase 2CD47CGRPant
SematapinarofLegend BiotechNDA/BLAVEGFCGRPant
HAL-9635HalozymePhase 2/3EZH2Cl18.2
RilufotisoranSamsung BiologicsNDA/BLAFXIaCGRPant