← Pipeline|Polacagene

Polacagene

Preclinical
PTN-5188
Source: Trial-derived·Trials: 2
Modality
mAb
MOA
GLP-1ag
Target
SMN2
Pathway
Notch
MS
Development Pipeline
Preclinical
Oct 2017
Jun 2030
PreclinicalCurrent
NCT08710084
2,668 pts·MS
2017-102030-06·Completed
NCT04165297
2,920 pts·MS
2020-112030-05·Completed
5,588 total pts1 indication
Phase 1
Phase 2
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (2)
2030-05-144.1y awayInterim· MS
2030-06-284.2y awayInterim· MS
Trial Timeline
Q3Q42018Q2Q3Q42019Q2Q3Q42020Q2Q3Q42021Q2Q3Q42022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q42029Q2Q3Q42030Q2Q3
Preclinical
Complet…
Preclinical
Complet…
Catalysts
Interim
2030-05-14 · 4.1y away
MS
Interim
2030-06-28 · 4.2y away
MS
Completed|StartCompletionToday
Trials (2)
NCTPhaseIndicationStatusNEP
NCT08710084PreclinicalMSCompleted2668CfB
NCT04165297PreclinicalMSCompleted2920EFS
Competitors (10)
DrugCompanyPhaseTargetMOA
PFE-8662PfizerNDA/BLACD19GLP-1ag
NVO-7840Novo NordiskPhase 2/3B7-H3GLP-1ag
NVO-6275Novo NordiskPhase 1SMN2BTKi
TAK-5300TakedaPhase 1SMN2AuroraAi
GIL-2259Gilead SciencesApprovedSMN2CAR-T CD19
REG-647RegeneronPreclinicalSMN2SOS1i
MRN-7601ModernaPhase 2IL-13GLP-1ag
ARG-1250ArgenxPhase 2C5GLP-1ag
ILM-5680IlluminaPhase 2BETGLP-1ag
CRS-184CRISPR TherapeuticsPhase 1/2AHRGLP-1ag