← Pipeline|Bemabrutinib

Bemabrutinib

Phase 1
ZLA-4277
Source: Trial-derived·Trials: 2
Modality
ERT
MOA
DLL3 ADC
Target
GPRC5D
Pathway
PD-1/PD-L1
NBCF
Development Pipeline
Preclinical
~Dec 2016
~Mar 2018
Phase 1
Jun 2018
Dec 2030
Phase 1Current
NCT08809291
1,141 pts·CF
2021-082030-12·Active
NCT08541773
118 pts·NB
2018-062026-08·Active
1,259 total pts2 indications
Phase 2
Phase 3
NDA/BLA
Approved
CompletedCurrentUpcoming
Catalysts (2)
2026-08-275mo awayInterim· NB
2030-12-034.7y awayInterim· CF
Trial Timeline
Q2Q3Q42019Q2Q3Q42020Q2Q3Q42021Q2Q3Q42022Q2Q3Q42023Q2Q3Q42024Q2Q3Q42025Q2Q3Q42026Q2Q3Q42027Q2Q3Q42028Q2Q3Q42029Q2Q3Q42030Q2Q3Q4
P1
Active
P1
Active
Catalysts
Interim
2026-08-27 · 5mo away
NB
Interim
2030-12-03 · 4.7y away
CF
Active|StartCompletionToday
Trials (2)
NCTPhaseIndicationStatusNEP
NCT08809291Phase 1CFActive1141ACR20
NCT08541773Phase 1NBActive118DAS28
Competitors (10)
DrugCompanyPhaseTargetMOA
PexatenlimabNovartisPhase 1/2GPRC5DKIF18Ai
NVS-4076NovartisPreclinicalTROP-2DLL3 ADC
RimamavacamtenMerck & CoPhase 1PI3KαDLL3 ADC
RibotuximabMerck & CoPhase 2GPRC5DEZH2i
BMY-9931Bristol-Myers SquibbPhase 1GPRC5DFXIai
NVO-7877Novo NordiskPreclinicalGPRC5DFXIai
AMG-9654AmgenPhase 2GPRC5DDLL3 ADC
GIL-9227Gilead SciencesPhase 2/3GPRC5DCDK2i
RibozanubrutinibGenmabApprovedGPRC5DTNFi
ASN-7408Ascendis PharmaNDA/BLAGPRC5DSTINGag